Dr. Jeremiah Scharf is a behavioral neurologist and neuropsychiatric geneticist whose academic interests lie in disorders that bridge the gap between traditional neurologic and psychiatric concepts of disease. Despite being a native New Yorker and a lapsed Yankees fan, Jeremiah moved to Boston after college and never left. He received his B.S. in Molecular Biophysics and Biochemistry from Yale University, and a combined M.D. from the Harvard-MIT Division of Health Sciences and Technology (HST) and Ph.D. in Neurobiology from Harvard University, where he worked with Dr. Louis Kunkel to identify modifying genes for spinal muscular atrophy. After completing Neurology residency at Mass General Brigham and a clinical fellowship in Behavioral Neurology/Neuropsychiatry, Jeremiah was drawn to Tourette Syndrome (TS) clinical care and research, since TS has long been considered a highly heritable, paradigmatic neuropsychiatric disorder, thus providing a unique opportunity to dissect the genetic and molecular basis of the brain circuitry at the interface of neurology and psychiatry and to use this knowledge to improve diagnosis, treatment and quality of life for individuals and families. In his post-doctoral work with Dr. David Pauls, he led the first genome-wide association study (GWAS) for Tourette Syndrome and co-led a parallel GWAS for OCD. As an independent CGM faculty member, he has overseen cross-disorder genetic analyses of TS and OCD, as well as multi-center GWAS, CNV, exome and whole-genome sequencing studies of TS and related disorders. The lab’s work has been supported by grants from the Tourette Association of America, the American Academy of Neurology, the TLC Foundation for Body-Focused Repetitive Behaviors (BFRBs), and the National Institutes of Health (NINDS, NIMH, and NHGRI).
MGB Collaborators
Joan A. Camprodon, M.D., M.P.H., Ph.D.
Dr. Joan Camprodon is the founding director of the MGH Transcranial Magnetic Stimulation (TMS) clinical service, a member of the Psychiatric Neurosurgery Committee and an attending physician in the departments of Psychiatry (Neuropsychiatry) and Neurology (Cognitive and Behavioral Neurology). He is board-certified in Psychiatry and Behavioral Neurology & Neuropsychiatry. Scientifically, Dr. Camprodon directs the Laboratory for Neuropsychiatry and Neuromodulation and is in the executive committee of the MGH Interdisciplinary Brain Center. His research uses multimodal combinations of neuroimaging and brain stimulation to investigate neural circuitry and plasticity in a translational manner. His laboratory works with a wide range of noninvasive and invasive neuromodulation techniques including transcranial electrical current stimulation (tECS), transcranial magnetic stimulation (TMS), electroconvulsive therapy (ECT) and deep brain stimulation (DBS) among others. He also uses functional and structural MRI and EEG, in addition to innovative combinations of TMS and tDCS with neuroimaging. Dr. Camprodon is interested in understanding basic circuit properties of human neural networks and how maladaptive plastic changes lead to neuropsychiatric disorders. The scope of his research includes basic, translational and clinical projects focused on circuit neuroscience. Current projects address the anatomy and physiology of disease-relevant networks as well as the investigation of pathophysiological mechanisms at the circuit level, with an emphasis on transdiagnostic processes and the role of plasticity. Critical translational efforts are geared towards applying the paradigms and methods of human systems neuroscience to develop practical and high-impact clinical tools with the potential to change how we practice medicine: e.g. identify biomarkers and predictors, discover treatment targets and design individualized precision therapies with an emphasis on device-based neuromodulation.
Jennifer L. Greenberg, Psy.D.
Jennifer L. Greenberg, Psy.D., received her Psy.D. in Clinical Psychology from Rutgers, the State University of New Jersey, in 2008. She completed her clinical internship and postdoctoral training at Massachusetts General Hospital/Harvard Medical School. Dr. Greenberg is a licensed clinical psychologist and sees patients in private practice. Her clinical and research background is in the cognitive-behavioral treatment of body image and obsessive compulsive spectrum disorders across the lifespan, with an emphasis on BDD. Her primary research interest resides in treatment outcome and cognitive risk factors that may play a role in the etiology and maintenance of these disorders. Clinically, she treats adolescents and adults with obsessive-compulsive spectrum disorders, including BDD and OCD, and eating disorders.
