here is the reference for the study of inositol in OCD
Fux M, Levine J, Aviv A, Belmaker RH: Inositol treatment of obsessive compulsive disorder. Am J Psychiatry 153:1219-1221, 1996
this is a summary from a chapter on drug treatment of OCD:
Inositol
As noted above, there is now considerable evidence that pharmacologic manipulation of the serotonergic system may help with OCD symptoms. Myo-inositol is a ubiquitous carbohydrate that is present in large amounts in brain tissue and is involved in neuronal signaling and osmoregulation (Vadnal et al, 1997) and, the phosphatidylinositol cycle is the second messenger system for several neurotransmitters, including several subtypes of serotonin receptors (Hoyter et al, 1994). In addition, desensitization of serotonin receptors is reversed by the addition of exogenous inositol (Rahman & Neuman, 1993). There are reports that exogenous inositol was effective in controlled trials for patients with depression and panic, and recently a research group performed a double-blind, controlled crossover trial of 18 grams/day of inositol versus placebo for 6 weeks each (Fux et al, 1996). The subjects had significantly lower scores on the YBOCS when taking inositol than when taking placebo.
best wishes,
Michael Jenike, MD
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